Two Arabidopsis Threonine Aldolases Are Nonredundant and Compete with Threonine Deaminase for a Common Substrate Pool

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Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate pool.

Amino acids are not only fundamental protein constituents but also serve as precursors for many essential plant metabolites. Although amino acid biosynthetic pathways in plants have been identified, pathway regulation, catabolism, and downstream metabolite partitioning remain relatively uninvestigated. Conversion of Thr to Gly and acetaldehyde by Thr aldolase (EC 4.1.2.5) was only recently show...

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Dissociation of the threonine deaminase of Ctostridium tetanomorfihum occurs upon exposure to heat, to alkaline pH, or to denaturing agents, or when preparations are diluted or allowed to age at -20°. Dissociation in the presence of urea, detergents, or an alkaline pH may be prevented by addition of adenosine diphosphate, threonine, phosphate buffer at pH 7.0, or monovalent or divalent cations....

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Threonine Deaminase of Clostridium tetanomorphum

Threonine deaminase (Lthreonine hydrolyase (deaminating), EC 4.2.1.16) has been purified approximately 700-fold from extracts of Clostridium tetanomorphum. Both threonine and serine can serve as substrates, but threonine is deaminated 5 to 10 times more rapidly than serine. Pyridoxal phosphate, a reducing agent, and alkaline pH are required for the deamination of either amino acid. A plot of th...

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Purified threonine deaminase of Salmonella typhimurium was found to be monodisperse and to have a molecular weight of 194,000. The protein, in 6 M guanidine HCI and 0.1 M P-mercaptoethanol, dissociates into polypeptide chains of molecular weight 48,500. Tryptic peptide analysis implies that the four component chains of the native enzyme are of identical amino acid sequence. L-Isoleucine and L-v...

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To determine the inducer(s) of the biodegradative threonine deaminase in Escherichia coli, the effects of various amino acids on the synthesis of this enzyme were investigated. The complex medium used hitherto for the enzyme induction can be completely replaced by a synthetic medium composed of 18 natural amino acids. In this synthetic medium, the omission of each of the seven amino acids threo...

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ژورنال

عنوان ژورنال: The Plant Cell

سال: 2006

ISSN: 1532-298X

DOI: 10.1105/tpc.106.044958